Simple suggestion to have the "IN" port on the GPU on the side facing the front of the case. This is the most likely place for a pump and/or reservoir placement and would be ideal in terms of utilizing the second hole as a drain.
This is how it looks on my build, and with the "in" port in the front i could have mounted the drain in the bottom out port:
This is how it looks on my build, and with the "in" port in the front i could have mounted the drain in the bottom out port: